The following applies to the ingredients: There is no definitive answer to this question as different pet owners will have different opinions about the use of medications like diphenhydramine for anxiety in their animals. Taking both medications has a moderate interaction, meaning: Moderately clinically significant. everything carries warnings. Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Benefits. ChildrenUse and dose must be determined by your doctor. Taking these drugs together raises your risk for serotonin syndrome. If your dog shows these symptoms, you should contact your vet immediately. Decontamination can be attempted, but the onset of clinical signs is typically too rapid to allow any emesis or activated charcoal. WebMD does not provide medical advice, diagnosis or treatment. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression. Create an account to follow your favorite communities and start taking part in conversations. If youve tried both methods in the video and you still cant get your dog to swallow the pill, then crushing it up in their food is often a great last resort (but best ask your vets advice first as some medications cannot be crushed). Dogs can't tell us if they don't like something or don't feel good. This medication will take effect quickly, in about 1 to 2 hours, when used for short-term stress relief, but for long-term treatment, this medication can take a few weeks before full effects are observed. i took 4 benadryl (diphenhydramine) to counter act. Your comment will be removed, and you may be banned. Benadryl Allergy - Does benedryl have any effect on blood sugar? How long does it take for trazodone to wear off? However, you should use them only when prescribed by a vet as using them together or in excess can lead to serious side effects. My dog (66 lbs boxer/hound mix) is prescribed apoquel daily by her current vet for allergies. The result is that more serotonin remains in your dog's system for longer. CBD might be an effective natural alternative. The articles published on this blog are for informational purposes only. Relievet is a family-owned business composed of a team of passionate pet parents that includes a Doctor of Pharmacy, a dog trainer, a writer, a psychologist, and more. How much Benadryl can I give my dog for anxiety? This amount can be administered two to three times daily, depending on your dogs symptoms. These medications may cause some risk when taken together. It comes in strengths ranging from 50 to 300mg per tablet. Benadryl is commonly used to treat itchiness in dogs caused by skin allergies, and it also reduces many of the other symptoms of allergies, including: Hives. A study in the Canadian Medical Association Journal found that seniors with dementia who were given trazodone as a sleep aid were as likely to fall as seniors given antipsychotics, other drugs. (found in Benadryl) and Trazodone. This is an automated general reminder to please follow The Sub Rules when discussing this question: Do not comment with anecdotes about your own or others' pets. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. We do this by using the highest quality natural ingredients, thoroughly testing our products and drawing from our years of experience volunteering and working with animals in veterinary practices. However, it is important to be familiar with the medication and discuss any potential side effects with your vet first. Veterinarians often prescribe Trazodone to help with severe behavioral issues like fear, aggression, and anxiety. Most frequently checked interactions View interaction reports for clindamycin and the medicines listed below. Do not stop using any medications without first talking to your doctor. Louis has been taking CBD oil for dogs ever since. A searchable list of possible drug interactions can be found here. Can 25mg of trazadone and benadryl (diphenhydramine) be taken together safely? Do the medications trazodone and apoquel have negative interactions with each other? Is that OK. Any action you take based on the information found on nahf.org is strictly at your discretion. Golden Retriever Rhodesian Ridgeback Mix (Golden Ridgeback) Info, Pictures, & Facts, Corgi Basenji Mix (Corsengi) Info, Pictures, & Facts, Boxer Bloodhound Mix Info, Pictures, & Facts, Catahoula Beagle Mix Info, Pictures, & Facts, Akita Doberman Mix (Doberkita Inu) Info, Pictures, & Facts) Info, Pictures, & Facts. By using our website, you consent to our use of cookies. I called to find out. But can dogs take trazodone and Benadryl together? Yes, most veterinarians will prescribe medication for dog anxiety as part of your pets treatment. This is due to an increase in serotonin levels in the dogs bloodstream, which can lead to irregular heartbeats and other cardiovascular problems. According to the Merck Veterinary Manual, the safe dosage is 2-4 milligrams of medication per kilogram of weight, or 0.9 to 1.8 milligrams per pound. Most diphenhydramine (Benadryl) tablets are 25 mg, which would be the appropriate size for a 25-pound dog. Can you take allergy pills with trazodone? The ASPCA Animal Poison Control Center reported 417 incidences involving single-agent trazodone exposures in 379 dogs from 2009 to 2013. Usually avoid combinations; use it only under special circumstances. I suggest you discuss this further with your Dr. West-Ward Pharmaceuticals Corporation (previously Roxane Laboratories Inc) In addition, certain breeds of dogs are also more prone to developing adverse reactions to vaccinations. If your dog experiences any side effects while taking trazodone and benadryl together, it is important to contact your veterinarian immediately. Daily life activities stopped for months. The drug would sedate me and put me to sleep. Moderate Benadryl + Trazodone The following applies to the ingredients: Diphenhydramine (found in Benadryl) and Trazodone Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. A common combo includes trazodone ~ 5 mg/kg and gabapentin ~ 20 mg/kg given 2 to 3 hours prior to travel. There is no one-size-fits-all answer to this question, as the best medication for an individual dog's anxiety and sleep disorder may vary depending on the individual animal's specific needs. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. There are a number of different drugs that can adversely affect dogs, and there are certain breeds of dogs that are more susceptible to these effects. Both have side effects, so it is important to talk to your veterinarian about the risks and benefits of each type of medication before they prescribe it. What are some common side effects of medication for dog anxiety? Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Benadryl (Diphenhydramine) is often better than other antihistamines at treating allergy symptoms and hives. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. I was prescribed Trazadone 50mg for anxiety and depression; eventually, my doses went up to 100mg and 150mg a day. Antianxiety drugs work by reducing anxiety symptoms, while antidepressant medications work by improving mood. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with traZODone. That said, in general, it is considered safe for dogs to take most medications, including the two drugs in question, for short periods of time. Use is not recommended.-According to some authorities: Use is contraindicated. Start by grinding plain oatmeal into a powder to sprinkle in your dogs warm bath. What to Do if a Dog Is Overexposed to Trazodone Incidence and Clinical Signs. The answer is yes. Anti-inflammatory drugs such as ibuprofen (Advil) or naproxen (Aleve) can be given to dogs to help reduce pain and swelling. Its an important question, too: these two drugs are incredibly common for addressing anxiety issues in dogs because they are both safe and effective on their own. Review our medical disclaimer. If it is necessary for a pet who is on one of these types of medications to start taking the other, veterinarians will typically recommend a wash-out period of around five days or so to prevent interactions between the drugs within the pets body. Some of the potential interactions between these two drugs include: Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. My dog (66 lbs boxer/hound mix) is prescribed apoquel daily by her current vet for allergies. If your dog is experiencing any of these side effects, they may need to be seen by a veterinarian and may require additional medical treatment. Although it would be bett --take the trazadone 2 hrs before bedtime & you should be ok. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Benadryl Allergy & Cold - I took two benadryl pills. Dr. Keto, Expert Animal models have failed to reveal evidence of impaired fertility or fetal harm at doses up to 5 times the human dose. For example, breeds such as the Labrador Retriever, Golden Retriever, and Shetland Sheepdog are particularly susceptible to adverse effects from drugs such as NSAIDs, corticosteroids, and certain antibiotics. Benadryl is a brand name of the drug Diphenhydramine, an over-the-counter, first-generation antihistamine that is accessible without a doctor's prescription.Diphenhydramine's main use involves the treatment of allergy symptoms, but it is also known for its sedative effects and thus is widely used as a sleep aid, too. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Trazodone treats depression and may help a person fall asleep. Do not use more than the recommended dose of traZODone, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. What to wash your dog with to stop itching? Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression. The effects of Trazodone can last for a day in healthy dogs and longer in those with kidney or liver issues. ARE THERE ANY NATURAL ALTERNATIVES TO TRAZODONE? Always follow your vets advice on the right dosages for your dog to avoid any complications. Generally, one would administer Benadryl orally in doses of 10 mg/kg (10 mg per pound) every six to eight hours while monitoring the animal for any side effects. Therefore, it is important to always consult with a veterinarian before starting any new medication regimen for your dog, including combining two drugs. -The potential for the drugs to interact with other medications Side effects of medication for dog anxiety can be pretty varied and depend on the drug being used and the individual pet's body chemistry. i took trazodone and it hasnt helped, so i tried a sleep 3 supplement with ashwaghanda, melatonin and gaba in it. The causes of adenomas in the stomach are common - heredity, developmental pathologies at the embryonic level, inflammatory diseases, mainly gastritis, junk food, alcoholism If these side effects are particularly bothersome, it is best to speak with a healthcare provider about adjusting the medications or dosages. It is important to be aware of these susceptibilities when selecting a medication for your dog, as they may require a different dosage or a different type of medication altogether. It can provide quick relief of allergy symptoms for both kids and adults. How long does 50mg trazodone last in dogs? How long can dogs safely take these two drugs together? "I began taking this around three months ago after the end of my marriage. The dosage for Trazodone for dogs ranges from 2.5 mg per pound to 15 mg per pound every 24 hours. These medications may cause some risk when taken together. This amount can be administered two to three times daily, depending on your dogs symptoms. CIMETIDINE/PROCAINAMIDE . Trazodone is a medication for depression in Tricyclic group. Trazodone costs around a dollar per tablet, with prices varying based on concentration. What can I give my dog to calm him down for grooming? Only after using it for two days did I realize there was no barking when the mailman came to the door. Should I avoid certain foods while taking Tagamet Oral? (2022): Cerner Multum, Inc. "Australian Product Information." Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. All meds have potential adverse effects and the more meds you are on increases this risk. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? If your dog weighs 25 lbs (11.3 kg) the dose of Benadryl would be 22.6mg to 45.2mg up to three times a day. Trazodone is an antidepressant that balances and increases serotonin levels in the brain. Last updated on 1 July 2019 by masso. I wouldn't think it prudent to pummel yourself to sleep with all of that. Other animal models have failed to reveal evidence of adverse effects on embryofetal development, parturition, or postnatal development when given at therapeutic doses. O 0. Yes and no. Moderately clinically significant. Trazodone is an antidepressant that is used in humans to treat anxiety, depression, and insomnia while Benadryl treats allergies and itching caused by pets or food items. Benadryl is commonly used to treat itchiness in dogs caused by skin allergies, and it also reduces many of the other symptoms of allergies, including: Hives. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. that you have: If your post already includes this information please disregard this message. Trazodone, Benadryl, and even Prozac are some of the many medications that can treat both humans and their furry pals. However, some people find that medications like trazodone are beneficial in some cases. Interactions between your drugs Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Trazodone for dogs is the same as the drug used by people. They suggested I try their CBD oil for dogs. Reach out to us any time, whether just to tell us your pet's story or for your vet to consult with James, our in-house Pharmacist; we would love to hear from you. This medication will take effect quickly, in about 1 to 2 hours, when used for short-term stress relief, but for long-term treatment, this medication can take a few weeks before full effects are observed. Disclaimer: This content should not be considered complete and should not be used in place of a call or visit to a healthcare professional. As far as the specific drugs in question, they are both commonly used to treat a variety of conditions in dogs. How to stop dog from biting other dogs' necks? Due to antipsychotics withdrawal i can't sleep. Some common side effects of trazodone include sedation, dizziness, and dry mouth. Things to remember when you fill your prescription. It is important to be aware of all of the potential interactions and side effects before taking either of these drugs. Always consult a licensed veterinarian if you have any health or behavior concerns about your pets. Anti-seizure medications such as phenobarbital or diazepam (Valium) may be prescribed for dogs who suffer from seizures. Taking both medications has a moderate interaction, meaning: Moderately clinically significant. Here are some antihistamine dosages for dogs: dexchlorpheniramine (Polaramine) this is a first gen. promethazine (Pherergan) this is also a first gen. fexofenadine (Telfast) this is a second gen. loratadine (Claratyne) also second gen. cetirizine (Zyrtec) also second gen. Your doctor may adjust your dose as needed. At first, I wasn't sure if it was working as there weren't any apparent effects. I was scared my depression had increased. I'm a lot calmer and haven't killed anyone.". Please copy the points below and edit your post to include the answers: Links to any test results, X-rays, vet reports etc. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. We comply with the HONcode standard for trustworthy health information. Comment: When this drug is used until delivery, newborns should be monitored for the occurrence of withdrawal symptoms. We comply with the HONcode standard for trustworthy health information. All along, it was the trazodone." In pet animals, trazodone has been shown to help treat aggression and panic disorders as well as cluster headaches and obsessive-compulsive disorders. Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. The general dose of Benadryl (diphenhydramine) is 2 to 4 mg/kg up to three times day. Why owners are supporting their pets well-being with Relievet products, Vet and Pharmacist approved holistic products. This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.-Some experts recommend: Use with caution; use should be avoided during the first trimester of pregnancy. Relievet provides pet owners with products they can trust to do the best for their pet family. How long will trazodone make a dog sleep? Comments:-The effects in the nursing infant are unknown.-The American Academy of Pediatrics considers this agent a drug for which the effect on nursing infants is unknown but may be of concern. Some mixtures of medications can lead to serious and even fatal consequences. So even the little bit of THC in some CBD products could have a negative effect on Louis, similar to what is possible with Trazodone. It is also possible that they could have a synergistic effect and help each other. Benadryl allergy - is diphenhydramine a drug used to make meth? We can not guarantee its completeness or reliability so please use caution. Here is a list of possible side effects: Serotonin Syndrome is a less common side effect that can be serious. If you experience any of these symptoms, talk with your doctor about whether its time for a dosage change. What happens if you give a dog too much trazodone? Always consult with a veterinarian before giving any medication to a dog, and follow the dosage recommendations provided by the vet. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness. Oatmeal Bath Oatmeal is an age-old remedy for our dry, itchy skin that happens to be safe for use on our canine friends, too! Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Can u take benadryl and trazodone together ? Even though I knew Louis wouldn't like it, it was time to visit the vet. Some additional benefits include: It has fewer side effects than many sleep aids, such as Ambien. Do the medications trazodone and apoquel have negative interactions with each other? Moderate Interactions. none have been romotely effective. While benadryl is over the counter and can be indicated for use in canines, it should not be given without instructions by a vet. Question: Can I Give My Dog Benadryl And Trazodone, Question: Can You Give A Dog Benadryl And Trazodone, Can I Give My Dog Benadryl And Trazodone Together, Can I Give My Dog Trazodone And Benadryl Together, Question: Can A Dog Take Benadryl With Trazodone, Question: Can My Dog Take Benadryl And Trazodone, Can I Give A Dog Trazodone If She Had Benadryl, Can Dogs Take Benadryl And Trazodone Together, Quick Answer: Can You Take Trazodone And Benadryl Together Dogs. Benadryl dosage for dogs. Learn More: What to do my dog killed my other dog? When combined with trazodone, CBD appeared to attenuate the effects of trazodone on plasma cortisol Sep 22, 2020. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. Avoid combinations; the risk of the interaction outweighs the benefit. Side Effects of Benadryl for Dogs | Canna-Pet, Trazodone For Dogs: How It Works & Signs Your Dog . Trazodone for Dogs Trazodone can be used as a treatment for anxiety and behavioral issues in dogs. Available for Android and iOS devices. I accidentally took lorazepam, trazodone, and Benadryl. Another option to avoid a full-on bath is to make an oatmeal paste. The two medications can be used to help manage anxiety and itching, respectively. Press question mark to learn the rest of the keyboard shortcuts. Always consult your healthcare provider before starting or stopping any medication. i've tried cbt, and i've tried trazodone, remeron, (mirtazapine) diphenhydramine and seroquil. Email this report to a friend, doctor, or patient. These classifications are only a guideline. Learn More: Why is my dog eating frozen dog poop? If anything, maybe just 25mg of Benadryl nightly. Can trazodone be used safely for long periods of time. Created for people with ongoing healthcare needs but benefits everyone. AU TGA pregnancy category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Do not give possible diagnoses that could explain the symptoms described by OP. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. (found in Benadryl). Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Over 600 drugs are known to interact with Trazodone. We also have trazodone from her past vet (we switched 6 months ago) for her bad car/boarding anxiety. When trazodone and Benadryl are used together, they are typically used to treat insomnia or anxiety. All rights reserved. Unfortunately, while he was less anxious, he was also less conscious. Quick Answer: Can You Give A Dog Benadryl With Trazodone. Using diphenhydramine together with trazodone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. If you are feeling particularly exhausted, it is best to avoid operating heavy machinery or driving. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression. Trazodone and Benadryl can be given together to your dog, but only under the supervision of a veterinarian. Can i take trazodone 50mg with vicks serve cold and flu? However, some typical side effects include drowsiness, loss of appetite, diarrhea, vomiting, weight loss. The interactions may result in drowsiness. stomach ulcer from aspirin or ibuprofen-like drugs, medication treatment for healing ulcer of the duodenum, increased stomach acid from systemic mastocytosis. I'm not sleeping at night. I take 50mg of trazadone/day. Taking Benadryl with melatonin, L-theanine, or trazodone could cause excessive sleepiness. These medications are not usually taken together. Philadelphia, PA: Wolters Kluwer Health Use of this content is subject to our terms of use & medical disclaimer. Trazodone and Benadryl can be given together to your dog, but only under the supervision of a veterinarian. Home Miscellaneous Quick Answer: Can You Give A Dog Benadryl With Trazodone. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression. At the ASPCA Animal Poison Control Center we become concerned with nave dogs who are exposed to trazodone at 5 mg/kg, though mild signs can be seen at doses lower than that. How long does trazodone take to kick in for dogs? HOW DOES TRAZODONE INTERACT WITH OTHER DRUGS? For these, please consult a doctor (virtually or in person). The two following reviews were rated as most helpful on drugs.com. While it may not directly cause harm, using an expired drug may have some negative effects including: Delay in appropriate treatment. It was developed and designed for humans but is prescribed off-label for dogs. The only way to safely euthanize a dog at home is with the presence of a veterinary professional or veterinarian. Benadryl may cause drowsiness, so it is important to use caution when operating machinery or driving after taking the medication. Please contact the moderators of this subreddit if you have any questions or concerns. You don't need a prescription to purchase Relievet products online or in stores in the United States and many other parts of the world. by Drugs.com After a single dose in a healthy adult, trazodone will be mostly out of your system in one to three days. Question posted by Adbell28 on 1 July 2019. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (>21 MG), STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB, SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (>50MG), SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (> 80 MG), WEAK CYP3A4 INHIBITORS/LOMITAPIDE (>30 MG), MODERATE CYP3A4 INHIBITORS/NALOXEGOL (> 12.5 MG), MODERATE CYP3A4 INHIBITORS/AVANAFIL (> 50 MG), DUAL WEAK CYP2C19 & MODERATE CYP3A4 INHIBITORS/MAVACAMTEN, DUAL CYP3A4 & WEAK CYP2D6 INHIBITORS/ELIGLUSTAT, H2 ANTAGONISTS; PROTON PUMP INHIBITORS/LEVOKETOCONAZOLE, P-GLYCOPROTEIN (P-GP) INHIBITORS/BILASTINE, P-GLYCOPROTEIN (P-GP) INHIBITORS/DOXORUBICIN, STRONG AND MODERATE CYP3A4 INHIBITORS/FEXINIDAZOLE, H2 ANTAGONISTS;PROTON PUMP INHIBITORS/METHYLPHENIDATE XR-ODT, H2 ANTAGONISTS; PROTON PUMP INHIBITORS/SOTORASIB, STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB, SELECTED MODERATE CYP3A4 INHIBITORS/ALPRAZOLAM, CIMETIDINE/CHLOROQUINE; HYDROXYCHLOROQUINE, P-GLYCOPROTEIN (P-GP) INHIBITORS/RELUGOLIX, LONG ACTING ANTACIDS; H2S;PPIS/SELECTED CEPHALOSPORINS, STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN, STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB, STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB, MODERATE CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR, P-GLYCOPROTEIN (P-GP) INHIBITORS/ORAL LEFAMULIN, H2 ANTAGONISTS; PROTON PUMP INHIBITORS/SECRETIN, P-GLYCOPROTEIN (P-GP) INHIBITORS/TALAZOPARIB, STRONG AND MODERATE CYP3A4 INHIBITORS/ENCORAFENIB, P-GLYCOPROTEIN (P-GP) INHIBITORS/COLCHICINE, MODERATE CYP3A4 INHIBITORS/NALOXEGOL (<= 12.5 MG), MODERATE CYP3A4 INHIBITORS/SUVOREXANT (> 10 MG), MODERATE CYP3A4 INHIBITORS/ERGOT ALKALOIDS, SELECTED MODERATE CYP3A4 INHIBITORS/PIMOZIDE, STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE, STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR, WEAK CYP3A4 INHIBITORS/LOMITAPIDE (<=30MG), SELECT CYP2C19 INHIBITORS/CITALOPRAM (>20 MG), ESOMEPRAZOLE; OMEPRAZOLE; CIMETIDINE/CLOPIDOGREL, ANTICHOLINERGICS/SOLID ORAL POTASSIUM CAPSULES, P-GLYCOPROTEIN (P-GP) INHIBITORS/TOPOTECAN, SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/DABIGATRAN, CIMETIDINE; PROTON PUMP INHIBITORS/POSACONAZOLE SUSPENSION, ANTICHOLINERGICS/SOLID ORAL POTASSIUM TABLETS, CIMETIDINE/SELECTED ANTICOAGULANTS (VIT K ANTAGONISTS), MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (<=21 MG), SLT MODERATE AND WEAK CYP3A4 INHIBIT/SIROLIMUS PROTEIN-BOUND, MODERATE AND WEAK CYP3A4 INHIBITORS/TACROLIMUS, SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (<= 80 MG), SELECTED MODERATE CYP3A4 INHIBITORS/IVOSIDENIB, SELECTED CYP2C19 INHIBITORS/ESCITALOPRAM (<= 15 MG), SELECT P-GP INHIBITORS/EDOXABAN (<= 30 MG), SEL ORAL CATIONS; ANTACIDS; H2 ANTAG/DOLUTEGRAVIR-RILPIVIRIN, SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/BETRIXABAN, H2 ANTAGONISTS/SELECTED KINASE INHIBITORS, SELECT P-GP INHIBITORS/EDOXABAN (> 30 MG), P-GP AND MODERATE CYP3A4 INHIBITORS/APIXABAN, P-GP AND SELECTED CYP3A4 INHIBITORS/NINTEDANIB, ANTACIDS; H2 ANTAGONISTS/LEDIPASVIR; VELPATASVIR, MODERATE CYP3A4 INHIBITORS/SUVOREXANT (<= 10 MG), MODERATE CYP3A4 INHIBITORS/AVANAFIL (<= 50 MG), P-GLYCOPROTEIN (P-GP) INHIBITORS/AFATINIB, SELECTED CYP2C19 INHIBITORS/ESCITALOPRAM (> 15 MG), SELECTED CYP2C19 INHIBITORS/CITALOPRAM (<= 20 MG), SELECTED P-GP AND WEAK CYP3A4 INHIBITORS/RIVAROXABAN, MODERATE CYP3A4; P-GP INHIBITORS/EVEROLIMUS, SELECTED WEAK CYP2D6 INHIBITORS/TAMOXIFEN, ANTACIDS;H2 ANTAGONISTS;PROTON PUMP INHIBITORS/AMPHETAMINES, CYP3A4; CYP2C8; P-GLYCOPROTEIN (P-GP) INHIBITORS/LOPERAMIDE, SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (<=50MG), SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/ETOPOSIDE, CIMETIDINE/SELECTED CALCIUM CHANNEL BLOCKERS, AGENTS AFFECTING GASTRIC PH/ITRACONAZOLE; KETOCONAZOLE.

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