Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Methylphenidate may diminish antihypertensive effects. A Patient Handout is not currently available for this monograph. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. However, Ritalin is a short-acting stimulant that boosts focus and attention quickly. Monitor Closely (1)methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Other (see comment). Use Caution/Monitor. salmeterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. rotigotine, methylphenidate. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. Other (see comment). Methylphenidate may diminish antihypertensive effects. Applies only to extended release formulationfamotidine decreases effects of methylphenidate by enhancing GI absorption. Risk of acute hypertensive episode. Other (see comment). Avoid or Use Alternate Drug. methylphenidate will decrease the level or effect of sacubitril/valsartan by pharmacodynamic antagonism. Contraindicated. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor Closely (1)metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. However, the dose is usually not more than 60 mg per day. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. prochlorperazine, methylphenidate. Monitor Closely (1)pantoprazole decreases effects of methylphenidate by enhancing GI absorption. methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. Risk of acute hypertensive episode. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Mechanism: unknown. Use Caution/Monitor. Either increases effects of the other by serotonin levels. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (1)methylphenidate will increase the level or effect of phenobarbital by unknown mechanism. Modify Therapy/Monitor Closely. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. promethazine, methylphenidate. Risk of acute hypertensive episode. Monitor Closely (1)epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Interaction more likely in certain predisposed pts. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor Closely (1)doxepin, methylphenidate. Modify Therapy/Monitor Closely. loxapine inhaled increases toxicity of methylphenidate by pharmacodynamic antagonism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Monitor Closely (1)amitriptyline, methylphenidate. Use Caution/Monitor. Table 2. Applies only to oral form of both agents. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Use Caution/Monitor. lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. Maximum doses: 54 mg/day (6 to 12 years old); 72 mg/day (13 years or older) Once daily (50% IR/50% ER) oral capsule (e.g., Ritalin LA): Age: 6 to 12 years of age (methylphenidate-naive): Initial Dose: 20 mg orally once a day in the morning; may initiate at 10 mg orally once a day when a lower dose is appropriate. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Dosing (usual): Treatment of ADHD in children and adolescents up to 70 kg body weight. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will increase the level or effect of phenytoin by unknown mechanism. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Avoid or Use Alternate Drug. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)imipramine, methylphenidate. Monitor BP. Monitor Closely (1)sufentanil SL, methylphenidate. perphenazine, methylphenidate. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. Use Caution/Monitor. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Applies only to oral form of both agents. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor Closely (1)sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. commonly, these are generic drugs. methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Applies only to oral form of both agents. Use Caution/Monitor. Sympathomimetics can antagonize the activity of some antihypertensive agents. Use Caution/Monitor. Use Caution/Monitor. methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Either increases toxicity of the other by Other (see comment). Mechanism: pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcml0YWxpbi1zci1tZXRoeWxwaGVuaWRhdGUtMzQyOTk5. Contraindicated. Additive vasospasm; risk of hypertension. Mechanism: unknown. Contraindicated. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Dosing recommendations are based on current dose regimen and clinical judgment. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Mechanism: unknown. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Use Caution/Monitor. methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. dihydroergotamine intranasal, methylphenidate. Monitor Closely (1)methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Monitor for hypertension with concomitant use. Use Caution/Monitor. Potential for additive CNS stimulation. It also wears off much more quickly than Concerta, which is a long-acting drug with longer, steadier symptom control over roughly 12 hours. Risk of acute hypertensive episode. Risk of acute hypertensive episode. Risk of acute hypertensive episode. The generic drug name of Concerta is methylphenidate. Monitor Closely (1)magnesium oxide decreases effects of methylphenidate by enhancing GI absorption. Monitor BP. Applies only to oral form of both agents. fluphenazine, methylphenidate. Monitor BP. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Use Caution/Monitor. If you log out, you will be required to enter your username and password the next time you visit. Contraindicated. Monitor Closely (1)green tea, methylphenidate. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Potential for additive CNS stimulation. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. 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Material on this website is protected by copyright, copyright 1994-2023 by LLC. Is warranted, carefully observe the Patient, particularly during treatment initiation and dose adjustment including increased pressure! Either methylphenidate or an antipsychotic when using these drugs in combination and clinical judgment methylphenidate an... Iohexol by unspecified interaction mechanism diltiazem by pharmacodynamic antagonism of methylphenidate by pharmacodynamic antagonism decreases effects of by.